Drug interactions
Butorphanol + Methohexital
Severity: Moderate
Butorphanol and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a short-acting barbiturate anesthetic, and with an opioid it produces greater sedation, respiratory depression and hypotension. This is a recognized effect in procedural sedation and anesthesia.
What this interaction means in plain words
Butorphanol and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression via opioid receptor activity and GABA-A potentiation by the barbiturate.
What to do
Use only where airway and ventilation can be supported and reduce doses of both agents. Monitor oxygenation, respiration and blood pressure continuously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Butorphanol and Methohexital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Methohexital
Frequently asked questions
Can I take Butorphanol with Methohexital?
MediHelp rates the interaction as moderate. Butorphanol and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a short-acting barbiturate anesthetic, and with an opioid it produces greater sedation, respiratory depression and hypotension. This is a recognized effect in procedural sedation and anesthesia.
How serious is the interaction between Butorphanol and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only where airway and ventilation can be supported and reduce doses of both agents. Monitor oxygenation, respiration and blood pressure continuously.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
