Drug interactions
Butorphanol + Oliceridine
Severity: Major
Butorphanol and Oliceridine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oliceridine is a full mu agonist, and butorphanol may add to sedation and respiratory depression. Butorphanol's partial antagonist activity can also reduce oliceridine analgesia or precipitate withdrawal in opioid-dependent patients.
What this interaction means in plain words
Butorphanol and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Butorphanol belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive opioid CNS depression with partial mu antagonism by butorphanol competing with oliceridine.
What to do
Avoid concurrent use, particularly in opioid-dependent patients. If both are given, monitor analgesia, respiration and withdrawal signs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Butorphanol with Oliceridine?
MediHelp rates the interaction as major. Butorphanol and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oliceridine is a full mu agonist, and butorphanol may add to sedation and respiratory depression. Butorphanol's partial antagonist activity can also reduce oliceridine analgesia or precipitate withdrawal in opioid-dependent patients.
How serious is the interaction between Butorphanol and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use, particularly in opioid-dependent patients. If both are given, monitor analgesia, respiration and withdrawal signs.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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