Drug interactions
Butorphanol + Orphenadrin
Severity: Moderate
Butorphanol and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has sedating central effects, and butorphanol is an opioid agonist-antagonist that causes drowsiness and respiratory depression. Taken together they can produce excessive sedation, impaired psychomotor performance and, at higher doses, respiratory depression.
What this interaction means in plain words
Butorphanol and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression from the two drugs.
What to do
Start butorphanol at the lowest effective dose and monitor for sedation and respiratory rate. Advise the patient not to drive or operate machinery until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Frequently asked questions
Can I take Butorphanol with Orphenadrin?
MediHelp rates the interaction as moderate. Butorphanol and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has sedating central effects, and butorphanol is an opioid agonist-antagonist that causes drowsiness and respiratory depression. Taken together they can produce excessive sedation, impaired psychomotor performance and, at higher doses, respiratory depression.
How serious is the interaction between Butorphanol and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start butorphanol at the lowest effective dose and monitor for sedation and respiratory rate. Advise the patient not to drive or operate machinery until the response is known.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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