Drug interactions
Butorphanol + Procarbazine
Severity: Moderate
Butorphanol and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity, and opioids given with MAO inhibitors may produce excessive sedation, respiratory depression and hypotension. The effect is mainly additive CNS and hemodynamic depression in this pairing.
What this interaction means in plain words
Butorphanol and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Procarbazine belongs to Oncology.
Why it happens
Weak MAO inhibition by procarbazine may potentiate opioid CNS depressant and hypotensive effects; the mechanism is not fully established.
What to do
Use a reduced initial butorphanol dose with careful titration, and monitor sedation, respiratory rate and blood pressure. Consider an alternative analgesic if the patient is already sedated or hypotensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Butorphanol and Procarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Butorphanol with Procarbazine?
MediHelp rates the interaction as moderate. Butorphanol and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak MAO-inhibiting activity, and opioids given with MAO inhibitors may produce excessive sedation, respiratory depression and hypotension. The effect is mainly additive CNS and hemodynamic depression in this pairing.
How serious is the interaction between Butorphanol and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a reduced initial butorphanol dose with careful titration, and monitor sedation, respiratory rate and blood pressure. Consider an alternative analgesic if the patient is already sedated or hypotensive.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
