Drug interactions
Butorphanol + Quetiapine
Severity: Moderate
Butorphanol and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is markedly sedating and can cause orthostatic hypotension, so combined use with an opioid may result in excessive drowsiness, dizziness and falls. Respiratory depression is possible in higher doses.
What this interaction means in plain words
Butorphanol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonism and quetiapine H1 and alpha-1 adrenergic blockade.
What to do
Monitor sedation and orthostatic blood pressure, and reduce doses if drowsiness is excessive. Counsel on fall risk and avoiding alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Butorphanol with Quetiapine?
MediHelp rates the interaction as moderate. Butorphanol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is markedly sedating and can cause orthostatic hypotension, so combined use with an opioid may result in excessive drowsiness, dizziness and falls. Respiratory depression is possible in higher doses.
How serious is the interaction between Butorphanol and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and orthostatic blood pressure, and reduce doses if drowsiness is excessive. Counsel on fall risk and avoiding alcohol.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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