Drug interactions
Butorphanol + Thioridazine
Severity: Moderate
Butorphanol and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and combining them can produce excessive drowsiness, impaired psychomotor performance and respiratory depression. Thioridazine also adds hypotension and QT prolongation risk in vulnerable patients.
What this interaction means in plain words
Butorphanol and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid agonist-antagonist and phenothiazine antipsychotic activity.
What to do
Start with the lowest butorphanol dose and monitor sedation, respiration and blood pressure. Check ECG and electrolytes if thioridazine is used, and warn the patient against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Butorphanol with Thioridazine?
MediHelp rates the interaction as moderate. Butorphanol and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and combining them can produce excessive drowsiness, impaired psychomotor performance and respiratory depression. Thioridazine also adds hypotension and QT prolongation risk in vulnerable patients.
How serious is the interaction between Butorphanol and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest butorphanol dose and monitor sedation, respiration and blood pressure. Check ECG and electrolytes if thioridazine is used, and warn the patient against driving.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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