Drug interactions
Butorphanol + Ziprasidone
Severity: Moderate
Butorphanol and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause drowsiness, and their combination may produce excessive sedation and orthostatic hypotension. Ziprasidone also prolongs the QT interval, which is not affected by butorphanol but matters in overall patient risk.
What this interaction means in plain words
Butorphanol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Butorphanol belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive CNS depression from opioid receptor agonism and antipsychotic antihistaminic and alpha-adrenergic blockade.
What to do
Use the lowest effective doses and monitor sedation, blood pressure and respiratory function. Counsel patients on avoiding driving and other CNS depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Butorphanol
- Butorphanol + Olanzapine / samidorphan Contraindicated
- Butorphanol + Sodium oxybate Contraindicated
- Alfentanil + Butorphanol Major
- Alprazolam + Butorphanol Major
- Alvimopan + Butorphanol Major
- Amobarbital + Butorphanol Major
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Butorphanol with Ziprasidone?
MediHelp rates the interaction as moderate. Butorphanol and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause drowsiness, and their combination may produce excessive sedation and orthostatic hypotension. Ziprasidone also prolongs the QT interval, which is not affected by butorphanol but matters in overall patient risk.
How serious is the interaction between Butorphanol and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, blood pressure and respiratory function. Counsel patients on avoiding driving and other CNS depressants.
What other medicines interact with Butorphanol?
MediHelp also lists interactions of Butorphanol with, for example, Olanzapine / samidorphan, Sodium oxybate, Alfentanil. The full list is on the Butorphanol page.
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