Drug interactions
Cabazitaxel + Cyclosporine
Severity: Moderate
Cabazitaxel and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase cabazitaxel concentrations. This raises the risk of neutropenia and gastrointestinal toxicity, in addition to additive immunosuppression.
What this interaction means in plain words
Cabazitaxel and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, reducing cabazitaxel clearance.
What to do
Monitor blood counts closely and consider reducing the cabazitaxel dose; consider alternative immunosuppression if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Cyclosporine?
MediHelp rates the interaction as moderate. Cabazitaxel and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits CYP3A4 and P-glycoprotein and may increase cabazitaxel concentrations. This raises the risk of neutropenia and gastrointestinal toxicity, in addition to additive immunosuppression.
How serious is the interaction between Cabazitaxel and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider reducing the cabazitaxel dose; consider alternative immunosuppression if feasible.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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