Drug interactions
Cabazitaxel + Diltiazem
Severity: Moderate
Cabazitaxel and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase cabazitaxel exposure, raising the risk of neutropenia and other toxicities.
What this interaction means in plain words
Cabazitaxel and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Diltiazem belongs to Cardiovascular.
Why it happens
Diltiazem inhibits CYP3A4, the main metabolic route of cabazitaxel.
What to do
Monitor blood counts closely and consider an alternative to diltiazem if feasible; reduce the cabazitaxel dose if severe toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Diltiazem?
MediHelp rates the interaction as moderate. Cabazitaxel and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase cabazitaxel exposure, raising the risk of neutropenia and other toxicities.
How serious is the interaction between Cabazitaxel and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts closely and consider an alternative to diltiazem if feasible; reduce the cabazitaxel dose if severe toxicity occurs.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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