Drug interactions
Cabazitaxel + Erythromycin ethylsuccinate
Severity: Moderate
Cabazitaxel and Erythromycin ethylsuccinate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin is a moderate CYP3A4 inhibitor and may increase cabazitaxel exposure. This can worsen neutropenia and diarrhea.
What this interaction means in plain words
Cabazitaxel and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated cabazitaxel metabolism.
What to do
Monitor blood counts and consider an alternative antibiotic such as azithromycin or reduce cabazitaxel dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Erythromycin ethylsuccinate?
MediHelp rates the interaction as moderate. Cabazitaxel and Erythromycin ethylsuccinate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin is a moderate CYP3A4 inhibitor and may increase cabazitaxel exposure. This can worsen neutropenia and diarrhea.
How serious is the interaction between Cabazitaxel and Erythromycin ethylsuccinate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and consider an alternative antibiotic such as azithromycin or reduce cabazitaxel dose if needed.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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