Drug interactions
Cabazitaxel + Fosamprenavir
Severity: Major
Cabazitaxel and Fosamprenavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, whose active form amprenavir inhibits CYP3A4, especially when boosted with ritonavir, may raise cabazitaxel exposure. This increases the risk of serious neutropenia and other toxicity.
What this interaction means in plain words
Cabazitaxel and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Amprenavir inhibits CYP3A4-mediated metabolism of cabazitaxel.
What to do
Avoid the combination. If necessary, consider reducing the cabazitaxel dose and monitor blood counts closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Fosamprenavir?
MediHelp rates the interaction as major. Cabazitaxel and Fosamprenavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fosamprenavir, whose active form amprenavir inhibits CYP3A4, especially when boosted with ritonavir, may raise cabazitaxel exposure. This increases the risk of serious neutropenia and other toxicity.
How serious is the interaction between Cabazitaxel and Fosamprenavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If necessary, consider reducing the cabazitaxel dose and monitor blood counts closely.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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