Drug interactions
Cabazitaxel + Fosphenytoin
Severity: Major
Cabazitaxel and Fosphenytoin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, the active metabolite, is a strong CYP3A4 inducer and may substantially lower cabazitaxel concentrations. This risks loss of anticancer efficacy.
What this interaction means in plain words
Cabazitaxel and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Fosphenytoin belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases cabazitaxel clearance.
What to do
Avoid if possible and switch to a non-inducing anticonvulsant such as levetiracetam; otherwise monitor response closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Cabazitaxel with Fosphenytoin?
MediHelp rates the interaction as major. Cabazitaxel and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin, the active metabolite, is a strong CYP3A4 inducer and may substantially lower cabazitaxel concentrations. This risks loss of anticancer efficacy.
How serious is the interaction between Cabazitaxel and Fosphenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and switch to a non-inducing anticonvulsant such as levetiracetam; otherwise monitor response closely.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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