Drug interactions
Cabazitaxel + Grapefruit
Severity: Minor
Cabazitaxel and Grapefruit: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit inhibits intestinal CYP3A4, but cabazitaxel is given intravenously so the effect is probably small. Nonetheless, increased exposure is theoretically possible.
What this interaction means in plain words
Cabazitaxel and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by grapefruit constituents, mainly in the gut wall.
What to do
Advise avoiding grapefruit products during treatment as a precaution.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Grapefruit?
MediHelp rates the interaction as minor. Cabazitaxel and Grapefruit have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit inhibits intestinal CYP3A4, but cabazitaxel is given intravenously so the effect is probably small. Nonetheless, increased exposure is theoretically possible.
How serious is the interaction between Cabazitaxel and Grapefruit?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding grapefruit products during treatment as a precaution.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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