Drug interactions
Cabazitaxel + Olaparib
Severity: Moderate
Cabazitaxel and Olaparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, and combining them can increase the frequency and duration of neutropenia, anemia and thrombocytopenia. Olaparib is also a weak CYP3A inhibitor.
What this interaction means in plain words
Cabazitaxel and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabazitaxel belongs to Oncology; Olaparib belongs to Oncology.
Why it happens
Additive myelosuppressive toxicity of a DNA-damaging PARP inhibitor and a cytotoxic taxane.
What to do
Monitor complete blood counts frequently and reduce doses or delay treatment for significant cytopenias; use G-CSF prophylaxis as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabazitaxel
Other interactions of Olaparib
- Amiodarone + Olaparib Major
- Amobarbital + Olaparib Major
- Apalutamide + Olaparib Major
- Aprepitant + Olaparib Major
- Azathioprine + Olaparib Major
- Carbamazepine + Olaparib Major
Frequently asked questions
Can I take Cabazitaxel with Olaparib?
MediHelp rates the interaction as moderate. Cabazitaxel and Olaparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, and combining them can increase the frequency and duration of neutropenia, anemia and thrombocytopenia. Olaparib is also a weak CYP3A inhibitor.
How serious is the interaction between Cabazitaxel and Olaparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay treatment for significant cytopenias; use G-CSF prophylaxis as appropriate.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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