Drug interactions
Cabazitaxel + Phenytoin
Severity: Major
Cabazitaxel and Phenytoin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, a strong CYP3A4 inducer, can lower cabazitaxel concentrations and reduce its anticancer efficacy. Cabazitaxel labeling advises avoiding strong inducers.
What this interaction means in plain words
Cabazitaxel and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cabazitaxel belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Induction of CYP3A4 increases cabazitaxel metabolism.
What to do
Avoid phenytoin and switch to a non-inducing antiseizure drug such as levetiracetam when possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cabazitaxel and Phenytoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Phenytoin?
MediHelp rates the interaction as major. Cabazitaxel and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin, a strong CYP3A4 inducer, can lower cabazitaxel concentrations and reduce its anticancer efficacy. Cabazitaxel labeling advises avoiding strong inducers.
How serious is the interaction between Cabazitaxel and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid phenytoin and switch to a non-inducing antiseizure drug such as levetiracetam when possible.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
