Drug interactions
Cabazitaxel + Typhoid vaccine live
Severity: Major
Cabazitaxel and Typhoid vaccine live: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabazitaxel causes immunosuppression, which raises the risk of infection from the live attenuated Salmonella Typhi strain and may reduce vaccine response.
What this interaction means in plain words
Cabazitaxel and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Chemotherapy-induced immunosuppression impairs control of live attenuated bacteria and reduces vaccine immune response.
What to do
Use the inactivated injectable typhoid vaccine instead of the live oral vaccine during cabazitaxel therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cabazitaxel
Frequently asked questions
Can I take Cabazitaxel with Typhoid vaccine live?
MediHelp rates the interaction as major. Cabazitaxel and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cabazitaxel causes immunosuppression, which raises the risk of infection from the live attenuated Salmonella Typhi strain and may reduce vaccine response.
How serious is the interaction between Cabazitaxel and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the inactivated injectable typhoid vaccine instead of the live oral vaccine during cabazitaxel therapy.
What other medicines interact with Cabazitaxel?
MediHelp also lists interactions of Cabazitaxel with, for example, Adenovirus types 4 and 7 live, Atazanavir, Bcg intravesical live. The full list is on the Cabazitaxel page.
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