Drug interactions
Cabergoline + Pramipexole
Severity: Moderate
Cabergoline and Pramipexole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are dopamine agonists, so combining them gives additive dopaminergic effects such as nausea, orthostatic hypotension, somnolence, hallucinations and impulse control disorders. They are sometimes used together deliberately, but adverse effects can be amplified.
What this interaction means in plain words
Cabergoline and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabergoline belongs to Endocrine; Pramipexole belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic dopamine D2-receptor agonism.
What to do
Use the lowest effective doses and monitor blood pressure, sedation, psychiatric symptoms and impulse control behaviors. Reduce one agent if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cabergoline
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Cabergoline with Pramipexole?
MediHelp rates the interaction as moderate. Cabergoline and Pramipexole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are dopamine agonists, so combining them gives additive dopaminergic effects such as nausea, orthostatic hypotension, somnolence, hallucinations and impulse control disorders. They are sometimes used together deliberately, but adverse effects can be amplified.
How serious is the interaction between Cabergoline and Pramipexole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor blood pressure, sedation, psychiatric symptoms and impulse control behaviors. Reduce one agent if adverse effects emerge.
What other medicines interact with Cabergoline?
MediHelp also lists interactions of Cabergoline with, for example, Benperidol, Chlorpromazine, Clarithromycin. The full list is on the Cabergoline page.
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