Drug interactions
Cabergoline + Promethazine
Severity: Contraindicated
Cabergoline and Promethazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The concurrent use of promethazine and cabergoline may reduce the therapeutic effects of cabergoline, potentially leading to inadequate management of conditions such as hyperprolactinemia. This interaction is particularly concerning as it may compromise the efficacy of cabergoline in controlling symptoms.
What this interaction means in plain words
Cabergoline and Promethazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cabergoline belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Promethazine is known to exert antagonistic effects on dopamine receptors, which can counteract the action of cabergoline, a dopamine agonist.
What to do
It is advisable to avoid co-administration of these two medications. If treatment with both is deemed necessary, close monitoring of the patient's response to cabergoline is essential, and alternative therapies should be considered.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Promethazine
- Dopamine + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
Other interactions of Cabergoline
Frequently asked questions
Can I take Cabergoline with Promethazine?
MediHelp rates the interaction as contraindicated. Cabergoline and Promethazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The concurrent use of promethazine and cabergoline may reduce the therapeutic effects of cabergoline, potentially leading to inadequate management of conditions such as hyperprolactinemia. This interaction is particularly concerning as it may compromise the efficacy of cabergoline in controlling symptoms.
How serious is the interaction between Cabergoline and Promethazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: It is advisable to avoid co-administration of these two medications. If treatment with both is deemed necessary, close monitoring of the patient's response to cabergoline is essential, and alternative therapies should be considered.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Dopamine, Ibutilide, Pimozide. The full list is on the Promethazine page.
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