Drug interactions
Dopamine + Promethazine
Severity: Contraindicated
Dopamine and Promethazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The concurrent use of promethazine and dopamine may lead to reduced efficacy of dopamine. This is primarily due to the antagonistic effects of promethazine on dopamine receptors, which can diminish the therapeutic outcomes expected from dopamine administration.
What this interaction means in plain words
Dopamine and Promethazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dopamine belongs to Cardiovascular; Promethazine belongs to Respiratory.
Why it happens
Promethazine acts as an antagonist at dopamine receptors, which interferes with the action of dopamine, a neurotransmitter that exerts various physiological effects.
What to do
It is advisable to avoid co-administration of these two drugs. If both are necessary for treatment, close monitoring of the patient's response to dopamine is essential, and alternative therapies should be considered.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Promethazine
- Cabergoline + Promethazine Contraindicated
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
- Desipramine + Dopamine Major
Frequently asked questions
Can I take Dopamine with Promethazine?
MediHelp rates the interaction as contraindicated. Dopamine and Promethazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The concurrent use of promethazine and dopamine may lead to reduced efficacy of dopamine. This is primarily due to the antagonistic effects of promethazine on dopamine receptors, which can diminish the therapeutic outcomes expected from dopamine administration.
How serious is the interaction between Dopamine and Promethazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: It is advisable to avoid co-administration of these two drugs. If both are necessary for treatment, close monitoring of the patient's response to dopamine is essential, and alternative therapies should be considered.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Cabergoline, Ibutilide, Pimozide. The full list is on the Promethazine page.
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