Drug interactions
Cabotegravir + Didanosine
Severity: Moderate
Cabotegravir and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabotegravir with rilpivirine is a complete regimen, so adding didanosine duplicates therapy. Didanosine also adds toxicities such as pancreatitis, neuropathy and lactic acidosis, and there is no data supporting the combination.
What this interaction means in plain words
Cabotegravir and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabotegravir belongs to Anti Virals; Didanosine belongs to Anti Virals.
Why it happens
No pharmacokinetic interaction is established; the concern is duplicate antiretroviral therapy outside a studied regimen.
What to do
Do not add didanosine to cabotegravir/rilpivirine. Select a single complete regimen suited to the patient.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Hydroxyurea Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Didanosine?
MediHelp rates the interaction as moderate. Cabotegravir and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabotegravir with rilpivirine is a complete regimen, so adding didanosine duplicates therapy. Didanosine also adds toxicities such as pancreatitis, neuropathy and lactic acidosis, and there is no data supporting the combination.
How serious is the interaction between Cabotegravir and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not add didanosine to cabotegravir/rilpivirine. Select a single complete regimen suited to the patient.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Hydroxyurea. The full list is on the Didanosine page.
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