Drug interactions
Cabotegravir + Stavudine
Severity: Moderate
Cabotegravir and Stavudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabotegravir given with rilpivirine is a complete HIV-1 treatment regimen, so adding stavudine creates redundant antiretroviral therapy. Stavudine also carries significant mitochondrial toxicity, and no data support the combination.
What this interaction means in plain words
Cabotegravir and Stavudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabotegravir belongs to Anti Virals; Stavudine belongs to Anti Virals.
Why it happens
No pharmacokinetic interaction is established; the concern is duplicate antiretroviral therapy outside a studied regimen.
What to do
Do not add stavudine to cabotegravir/rilpivirine therapy. Choose one complete regimen, and move off stavudine to a better tolerated agent if it is still in use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Stavudine
- Didanosine + Stavudine Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Stavudine Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Stavudine Major
- Betibeglogene autotemcel + Stavudine Major
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Stavudine?
MediHelp rates the interaction as moderate. Cabotegravir and Stavudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabotegravir given with rilpivirine is a complete HIV-1 treatment regimen, so adding stavudine creates redundant antiretroviral therapy. Stavudine also carries significant mitochondrial toxicity, and no data support the combination.
How serious is the interaction between Cabotegravir and Stavudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not add stavudine to cabotegravir/rilpivirine therapy. Choose one complete regimen, and move off stavudine to a better tolerated agent if it is still in use.
What other medicines interact with Stavudine?
MediHelp also lists interactions of Stavudine with, for example, Didanosine, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide. The full list is on the Stavudine page.
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