Drug interactions
Cabozantinib + Chloramphenicol
Severity: Moderate
Cabozantinib and Chloramphenicol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabozantinib is a CYP3A4 substrate, so chloramphenicol may increase its exposure and the risk of diarrhea, hypertension, hand-foot syndrome and hemorrhage.
What this interaction means in plain words
Cabozantinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Chloramphenicol belongs to Anti Bacterial.
Why it happens
Inhibition of CYP3A4-mediated metabolism of cabozantinib.
What to do
Use an alternative antibiotic if possible. If combined, monitor for cabozantinib adverse effects and reduce its dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Chloramphenicol
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Chloramphenicol?
MediHelp rates the interaction as moderate. Cabozantinib and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cabozantinib is a CYP3A4 substrate, so chloramphenicol may increase its exposure and the risk of diarrhea, hypertension, hand-foot syndrome and hemorrhage.
How serious is the interaction between Cabozantinib and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic if possible. If combined, monitor for cabozantinib adverse effects and reduce its dose as needed.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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