Drug interactions
Cabozantinib + Cimetidine
Severity: Minor
Cabozantinib and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cabozantinib is a CYP3A4 substrate, and cimetidine may modestly raise its exposure. Increased levels could worsen diarrhea, hypertension, hand-foot syndrome and bleeding risk. Effect of a weak inhibitor is expected to be small.
What this interaction means in plain words
Cabozantinib and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cabozantinib belongs to Oncology; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine weakly inhibits CYP3A4-mediated cabozantinib metabolism.
What to do
No dose change is routinely needed; monitor for cabozantinib toxicity such as diarrhea and hypertension.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cabozantinib and Cimetidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Cimetidine?
MediHelp rates the interaction as minor. Cabozantinib and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cabozantinib is a CYP3A4 substrate, and cimetidine may modestly raise its exposure. Increased levels could worsen diarrhea, hypertension, hand-foot syndrome and bleeding risk. Effect of a weak inhibitor is expected to be small.
How serious is the interaction between Cabozantinib and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for cabozantinib toxicity such as diarrhea and hypertension.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
