Drug interactions
Cabozantinib + Imatinib
Severity: Moderate
Cabozantinib and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib may raise cabozantinib exposure through CYP3A4 inhibition. This can increase the risk of diarrhea, hypertension, hand-foot syndrome, hemorrhage and hepatotoxicity.
What this interaction means in plain words
Cabozantinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP3A4-mediated metabolism of cabozantinib, decreasing its clearance.
What to do
Avoid if possible. If coadministration is required, reduce the cabozantinib dose according to labeling and monitor for toxicity; resume the previous dose 2-3 days after imatinib is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Imatinib?
MediHelp rates the interaction as moderate. Cabozantinib and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib may raise cabozantinib exposure through CYP3A4 inhibition. This can increase the risk of diarrhea, hypertension, hand-foot syndrome, hemorrhage and hepatotoxicity.
How serious is the interaction between Cabozantinib and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If coadministration is required, reduce the cabozantinib dose according to labeling and monitor for toxicity; resume the previous dose 2-3 days after imatinib is stopped.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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