Drug interactions
Cabozantinib + Lapatinib
Severity: Moderate
Cabozantinib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib is a CYP3A4 inhibitor and cabozantinib is a CYP3A4 substrate, so cabozantinib exposure may rise. This may increase cabozantinib toxicities such as diarrhea, hypertension, hand-foot syndrome and hemorrhage.
What this interaction means in plain words
Cabozantinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Lapatinib inhibits CYP3A4, reducing the metabolism of cabozantinib.
What to do
Monitor for cabozantinib adverse effects and reduce its dose if toxicity develops. Review the combination if tolerability worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Lapatinib?
MediHelp rates the interaction as moderate. Cabozantinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lapatinib is a CYP3A4 inhibitor and cabozantinib is a CYP3A4 substrate, so cabozantinib exposure may rise. This may increase cabozantinib toxicities such as diarrhea, hypertension, hand-foot syndrome and hemorrhage.
How serious is the interaction between Cabozantinib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib adverse effects and reduce its dose if toxicity develops. Review the combination if tolerability worsens.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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