Drug interactions
Cabozantinib + Mifepristone
Severity: Moderate
Cabozantinib and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase cabozantinib concentrations through CYP3A4 inhibition. Greater exposure may increase the risk of hemorrhage, diarrhea, hypertension and hand-foot syndrome.
What this interaction means in plain words
Cabozantinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 metabolism of cabozantinib by mifepristone.
What to do
Avoid if possible, or reduce the cabozantinib dose per labeling and monitor for adverse effects. Resume the original dose 2 to 3 days after mifepristone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Mifepristone?
MediHelp rates the interaction as moderate. Cabozantinib and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may increase cabozantinib concentrations through CYP3A4 inhibition. Greater exposure may increase the risk of hemorrhage, diarrhea, hypertension and hand-foot syndrome.
How serious is the interaction between Cabozantinib and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or reduce the cabozantinib dose per labeling and monitor for adverse effects. Resume the original dose 2 to 3 days after mifepristone is stopped.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
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