Drug interactions
Cabozantinib + Nicardipine
Severity: Moderate
Cabozantinib and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine may modestly raise cabozantinib levels through CYP3A4 inhibition. This could increase risk of diarrhea, hypertension, hand-foot syndrome and hemorrhage.
What this interaction means in plain words
Cabozantinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by nicardipine reduces cabozantinib clearance.
What to do
Monitor blood pressure and for cabozantinib toxicity, and reduce the dose if adverse effects occur. Strong-inhibitor dose reductions are not routinely required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Nicardipine?
MediHelp rates the interaction as moderate. Cabozantinib and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine may modestly raise cabozantinib levels through CYP3A4 inhibition. This could increase risk of diarrhea, hypertension, hand-foot syndrome and hemorrhage.
How serious is the interaction between Cabozantinib and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and for cabozantinib toxicity, and reduce the dose if adverse effects occur. Strong-inhibitor dose reductions are not routinely required.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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