Drug interactions
Cabozantinib + Quinidine
Severity: Moderate
Cabozantinib and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a CYP3A4 inhibitor, though not a strong one, and may raise cabozantinib levels, increasing toxicities such as diarrhea, hypertension and hand-foot syndrome. Both drugs can also affect QT.
What this interaction means in plain words
Cabozantinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 (and P-glycoprotein) reduces cabozantinib clearance.
What to do
Monitor for cabozantinib adverse effects and ECG, and reduce the cabozantinib dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Quinidine?
MediHelp rates the interaction as moderate. Cabozantinib and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a CYP3A4 inhibitor, though not a strong one, and may raise cabozantinib levels, increasing toxicities such as diarrhea, hypertension and hand-foot syndrome. Both drugs can also affect QT.
How serious is the interaction between Cabozantinib and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib adverse effects and ECG, and reduce the cabozantinib dose if toxicity occurs.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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