Drug interactions
Cabozantinib + Sertraline
Severity: Minor
Cabozantinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline weakly inhibits CYP3A4 and may slightly increase cabozantinib exposure. The effect is expected to be small.
What this interaction means in plain words
Cabozantinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cabozantinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline reduces cabozantinib metabolism.
What to do
No dose adjustment is routinely needed. Monitor for diarrhea, hypertension and hand-foot syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cabozantinib and Sertraline, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Sertraline?
MediHelp rates the interaction as minor. Cabozantinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sertraline weakly inhibits CYP3A4 and may slightly increase cabozantinib exposure. The effect is expected to be small.
How serious is the interaction between Cabozantinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is routinely needed. Monitor for diarrhea, hypertension and hand-foot syndrome.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
