Drug interactions
Cabozantinib + Ticagrelor
Severity: Moderate
Cabozantinib and Ticagrelor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticagrelor is a weak CYP3A4 inhibitor and cabozantinib is a CYP3A4 substrate, so cabozantinib exposure could rise slightly. The expected effect is small, but cabozantinib itself carries a bleeding risk that overlaps with the antiplatelet effect of ticagrelor.
What this interaction means in plain words
Cabozantinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Ticagrelor belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by ticagrelor, plus additive bleeding tendency from the two drugs.
What to do
Monitor for cabozantinib adverse effects such as diarrhea, hypertension and hand-foot syndrome, and for bleeding. Reduce the cabozantinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Ticagrelor?
MediHelp rates the interaction as moderate. Cabozantinib and Ticagrelor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticagrelor is a weak CYP3A4 inhibitor and cabozantinib is a CYP3A4 substrate, so cabozantinib exposure could rise slightly. The expected effect is small, but cabozantinib itself carries a bleeding risk that overlaps with the antiplatelet effect of ticagrelor.
How serious is the interaction between Cabozantinib and Ticagrelor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib adverse effects such as diarrhea, hypertension and hand-foot syndrome, and for bleeding. Reduce the cabozantinib dose if toxicity develops.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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