Drug interactions
Cabozantinib + Verapamil
Severity: Moderate
Cabozantinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor and may raise cabozantinib concentrations, though the effect of moderate inhibitors is modest. Higher exposure could worsen diarrhea, hypertension and hand-foot syndrome.
What this interaction means in plain words
Cabozantinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cabozantinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 metabolism of cabozantinib.
What to do
Monitor for cabozantinib toxicity and reduce the dose if adverse effects emerge; consider an alternative antihypertensive if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Cabozantinib
Frequently asked questions
Can I take Cabozantinib with Verapamil?
MediHelp rates the interaction as moderate. Cabozantinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is a moderate CYP3A4 inhibitor and may raise cabozantinib concentrations, though the effect of moderate inhibitors is modest. Higher exposure could worsen diarrhea, hypertension and hand-foot syndrome.
How serious is the interaction between Cabozantinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cabozantinib toxicity and reduce the dose if adverse effects emerge; consider an alternative antihypertensive if feasible.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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