Drug interactions
Caffeine + Clemastine
Severity: Minor
Caffeine and Clemastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a stimulant and may partly offset clemastine's drowsiness. The offset is incomplete and does not reliably restore psychomotor performance.
What this interaction means in plain words
Caffeine and Clemastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Clemastine belongs to Respiratory.
Why it happens
Caffeine's adenosine-receptor antagonism opposes sedation from H1 blockade; there is no significant pharmacokinetic interaction.
What to do
No action is generally needed. Do not rely on caffeine to counteract sedation when driving.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Clemastine
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Clemastine?
MediHelp rates the interaction as minor. Caffeine and Clemastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is a stimulant and may partly offset clemastine's drowsiness. The offset is incomplete and does not reliably restore psychomotor performance.
How serious is the interaction between Caffeine and Clemastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Do not rely on caffeine to counteract sedation when driving.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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