Drug interactions
Caffeine + Fezolinetant
Severity: Major
Caffeine and Fezolinetant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fezolinetant is cleared mainly by CYP1A2, and caffeine is a CYP1A2 substrate that can compete for this enzyme. Reduced clearance could raise fezolinetant exposure and increase the risk of adverse effects including liver injury. The labeled contraindication concerns CYP1A2 inhibitors; ordinary dietary caffeine is a weak interaction, but it is flagged here.
What this interaction means in plain words
Caffeine and Fezolinetant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Caffeine belongs to Miscellaneous; Fezolinetant belongs to Endocrine.
Why it happens
Competition for CYP1A2 metabolism may reduce fezolinetant clearance and increase its plasma concentrations.
What to do
Counsel patients to limit caffeine intake, especially high doses or caffeine-containing medicines, during fezolinetant therapy. Monitor liver tests per fezolinetant labeling and for adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
- Caffeine + Ciprofloxacin Moderate
Other interactions of Fezolinetant
- Cimetidine + Fezolinetant Contraindicated
- Ciprofloxacin + Fezolinetant Contraindicated
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contraindicated
Frequently asked questions
Can I take Caffeine with Fezolinetant?
MediHelp rates the interaction as major. Caffeine and Fezolinetant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fezolinetant is cleared mainly by CYP1A2, and caffeine is a CYP1A2 substrate that can compete for this enzyme. Reduced clearance could raise fezolinetant exposure and increase the risk of adverse effects including liver injury. The labeled contraindication concerns CYP1A2 inhibitors; ordinary dietary caffeine is a weak interaction, but it is flagged here.
How serious is the interaction between Caffeine and Fezolinetant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to limit caffeine intake, especially high doses or caffeine-containing medicines, during fezolinetant therapy. Monitor liver tests per fezolinetant labeling and for adverse effects.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Methylenedioxymethamphetamine, Selegiline transdermal. The full list is on the Caffeine page.
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