Drug interactions
Caffeine + Esketamine intranasal
Severity: Moderate
Caffeine and Esketamine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esketamine causes transient increases in blood pressure and heart rate, and caffeine as a stimulant may add to these effects. This can raise the risk of hypertensive responses around dosing.
What this interaction means in plain words
Caffeine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathetic stimulation and pressor effects.
What to do
Check blood pressure before and after esketamine dosing and consider limiting caffeine on treatment days; delay dosing if baseline pressure is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Esketamine intranasal?
MediHelp rates the interaction as moderate. Caffeine and Esketamine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esketamine causes transient increases in blood pressure and heart rate, and caffeine as a stimulant may add to these effects. This can raise the risk of hypertensive responses around dosing.
How serious is the interaction between Caffeine and Esketamine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before and after esketamine dosing and consider limiting caffeine on treatment days; delay dosing if baseline pressure is elevated.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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