Drug interactions
Caffeine + Esketamine
Severity: Minor
Caffeine and Esketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine is a mild stimulant that can modestly raise blood pressure and heart rate, adding to esketamine's transient hemodynamic effects. At dietary intake the effect is typically small.
What this interaction means in plain words
Caffeine and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Caffeine belongs to Miscellaneous; Esketamine belongs to Central Nervous System.
Why it happens
Additive mild sympathomimetic stimulation.
What to do
Routine blood pressure monitoring around esketamine dosing is sufficient. Advise avoiding large amounts of caffeine on treatment days.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esketamine
Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Esketamine?
MediHelp rates the interaction as minor. Caffeine and Esketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine is a mild stimulant that can modestly raise blood pressure and heart rate, adding to esketamine's transient hemodynamic effects. At dietary intake the effect is typically small.
How serious is the interaction between Caffeine and Esketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Routine blood pressure monitoring around esketamine dosing is sufficient. Advise avoiding large amounts of caffeine on treatment days.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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