Drug interactions
Caffeine + Fexinidazole
Severity: Moderate
Caffeine and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP1A2, reducing caffeine clearance and increasing caffeine exposure. This can lead to stimulant effects such as tremor, insomnia or palpitations.
What this interaction means in plain words
Caffeine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated caffeine metabolism.
What to do
Avoid or limit caffeine-containing beverages and products during the fexinidazole course, and monitor for signs of caffeine excess.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Fexinidazole?
MediHelp rates the interaction as moderate. Caffeine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP1A2, reducing caffeine clearance and increasing caffeine exposure. This can lead to stimulant effects such as tremor, insomnia or palpitations.
How serious is the interaction between Caffeine and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid or limit caffeine-containing beverages and products during the fexinidazole course, and monitor for signs of caffeine excess.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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