Drug interactions
Caffeine + Iobenguane i
Severity: Moderate
Caffeine and Iobenguane i: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane I-131 relies on the norepinephrine transporter to enter neuroendocrine tumour cells. Caffeine is a sympathomimetic stimulant, and agents that interfere with catecholamine uptake or storage may lower tumour uptake of the radiopharmaceutical and reduce therapeutic or imaging performance. The clinical impact of dietary caffeine is uncertain, but the label lists interfering drugs as a concern.
What this interaction means in plain words
Caffeine and Iobenguane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible interference with catecholamine uptake or storage mechanisms needed for cellular uptake of iobenguane; the effect of caffeine itself is not well established.
What to do
Avoid caffeine-containing medicines and consider limiting dietary caffeine in the days before and after dosimetry and therapeutic iobenguane doses, following the product label timing for interfering drugs. Confirm tumour uptake on imaging.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Iobenguane i?
MediHelp rates the interaction as moderate. Caffeine and Iobenguane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iobenguane I-131 relies on the norepinephrine transporter to enter neuroendocrine tumour cells. Caffeine is a sympathomimetic stimulant, and agents that interfere with catecholamine uptake or storage may lower tumour uptake of the radiopharmaceutical and reduce therapeutic or imaging performance. The clinical impact of dietary caffeine is uncertain, but the label lists interfering drugs as a concern.
How serious is the interaction between Caffeine and Iobenguane i?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid caffeine-containing medicines and consider limiting dietary caffeine in the days before and after dosimetry and therapeutic iobenguane doses, following the product label timing for interfering drugs. Confirm tumour uptake on imaging.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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