Drug interactions
Caffeine + Levorphanol
Severity: Minor
Caffeine and Levorphanol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Caffeine may lessen the drowsiness from levorphanol and give a misleading impression of alertness. It does not prevent opioid-related respiratory depression.
What this interaction means in plain words
Caffeine and Levorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing pharmacodynamic effects on CNS arousal.
What to do
Monitor respiratory rate and sedation independent of subjective alertness; no dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Levorphanol?
MediHelp rates the interaction as minor. Caffeine and Levorphanol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Caffeine may lessen the drowsiness from levorphanol and give a misleading impression of alertness. It does not prevent opioid-related respiratory depression.
How serious is the interaction between Caffeine and Levorphanol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor respiratory rate and sedation independent of subjective alertness; no dose adjustment is needed.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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