Drug interactions
Caffeine + Metaproterenol
Severity: Moderate
Caffeine and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents stimulate the sympathetic and central nervous systems and can cause additive tremor, palpitations, tachycardia and nervousness. This is more important in patients with arrhythmia or heart disease.
What this interaction means in plain words
Caffeine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation: beta-agonism by metaproterenol plus caffeine's phosphodiesterase inhibition and catecholamine release.
What to do
Monitor heart rate, tremor and blood pressure, and advise limiting caffeine intake. Reduce caffeine or review the bronchodilator dose if adrenergic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Metaproterenol?
MediHelp rates the interaction as moderate. Caffeine and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents stimulate the sympathetic and central nervous systems and can cause additive tremor, palpitations, tachycardia and nervousness. This is more important in patients with arrhythmia or heart disease.
How serious is the interaction between Caffeine and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, tremor and blood pressure, and advise limiting caffeine intake. Reduce caffeine or review the bronchodilator dose if adrenergic symptoms occur.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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