Drug interactions
Caffeine + Pefloxacin
Severity: Moderate
Caffeine and Pefloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pefloxacin inhibits caffeine metabolism and reduces its clearance, raising caffeine levels and half-life. This may cause jitteriness, insomnia, tachycardia and, at high intake, seizures or arrhythmias.
What this interaction means in plain words
Caffeine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Caffeine belongs to Miscellaneous; Pefloxacin belongs to Anti Bacterial.
Why it happens
Inhibition of CYP1A2-mediated caffeine metabolism by pefloxacin.
What to do
Advise patients to reduce caffeine intake while taking pefloxacin and watch for tremor, insomnia, palpitations or agitation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Other interactions of Pefloxacin
- Pefloxacin + Tizanidine Contraindicated
- Clozapine + Pefloxacin Major
- Duloxetine + Pefloxacin Major
- Pefloxacin + Theophylline Major
- Asenapine + Pefloxacin Moderate
- Cimetidine + Pefloxacin Moderate
Frequently asked questions
Can I take Caffeine with Pefloxacin?
MediHelp rates the interaction as moderate. Caffeine and Pefloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pefloxacin inhibits caffeine metabolism and reduces its clearance, raising caffeine levels and half-life. This may cause jitteriness, insomnia, tachycardia and, at high intake, seizures or arrhythmias.
How serious is the interaction between Caffeine and Pefloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to reduce caffeine intake while taking pefloxacin and watch for tremor, insomnia, palpitations or agitation.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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