Drug interactions
Caffeine + Pipemidic acid
Severity: Moderate
Caffeine and Pipemidic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pipemidic acid, a quinolone antibacterial, inhibits caffeine metabolism and can raise caffeine concentrations and prolong its half-life. This may increase stimulant effects such as insomnia, restlessness, tremor and palpitations.
What this interaction means in plain words
Caffeine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated caffeine metabolism by pipemidic acid.
What to do
Advise patients to reduce caffeine intake during treatment and watch for CNS stimulation or palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Pipemidic acid?
MediHelp rates the interaction as moderate. Caffeine and Pipemidic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pipemidic acid, a quinolone antibacterial, inhibits caffeine metabolism and can raise caffeine concentrations and prolong its half-life. This may increase stimulant effects such as insomnia, restlessness, tremor and palpitations.
How serious is the interaction between Caffeine and Pipemidic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to reduce caffeine intake during treatment and watch for CNS stimulation or palpitations.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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