Drug interactions
Caffeine + Yerba mate
Severity: Moderate
Caffeine and Yerba mate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yerba mate contains caffeine and other methylxanthines, so combining it with caffeine adds to stimulant effects. High combined intake may cause anxiety, insomnia, tachycardia and palpitations.
What this interaction means in plain words
Caffeine and Yerba mate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adenosine receptor antagonism from caffeine and methylxanthines in yerba mate.
What to do
Include yerba mate caffeine in total daily intake and limit combined use in patients with cardiac arrhythmias, hypertension or anxiety.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Caffeine
- Caffeine + Ephedrine Major
- Caffeine + Fezolinetant Major
- Caffeine + Methylenedioxymethamphetamine Major
- Caffeine + Selegiline transdermal Major
- Adenosine + Caffeine Moderate
- Benzphetamine + Caffeine Moderate
Frequently asked questions
Can I take Caffeine with Yerba mate?
MediHelp rates the interaction as moderate. Caffeine and Yerba mate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yerba mate contains caffeine and other methylxanthines, so combining it with caffeine adds to stimulant effects. High combined intake may cause anxiety, insomnia, tachycardia and palpitations.
How serious is the interaction between Caffeine and Yerba mate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Include yerba mate caffeine in total daily intake and limit combined use in patients with cardiac arrhythmias, hypertension or anxiety.
What other medicines interact with Caffeine?
MediHelp also lists interactions of Caffeine with, for example, Ephedrine, Fezolinetant, Methylenedioxymethamphetamine. The full list is on the Caffeine page.
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