Drug interactions
Calcium + Captopril
Severity: Minor
Calcium and Captopril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids including calcium carbonate may modestly reduce the oral bioavailability of captopril. The clinical impact is usually small but blood pressure control could be slightly reduced.
What this interaction means in plain words
Calcium and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Captopril belongs to Cardiovascular.
Why it happens
Antacid-related changes in gastric environment and binding may reduce captopril absorption; the mechanism is not firmly established.
What to do
Separate captopril from calcium carbonate by about 2 hours and monitor blood pressure.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Captopril
- Aliskiren + Captopril Contraindicated
- Captopril + Sacubitril / valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Amifostine + Captopril Major
- Amiloride + Captopril Major
- Amlodipine-hydrochlorothiazide-valsartan + Captopril Major
Frequently asked questions
Can I take Calcium with Captopril?
MediHelp rates the interaction as minor. Calcium and Captopril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids including calcium carbonate may modestly reduce the oral bioavailability of captopril. The clinical impact is usually small but blood pressure control could be slightly reduced.
How serious is the interaction between Calcium and Captopril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate captopril from calcium carbonate by about 2 hours and monitor blood pressure.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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