Drug interactions
Calcium + Dabrafenib
Severity: Moderate
Calcium and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib solubility is pH-dependent, so agents that raise gastric pH, including calcium carbonate antacids, may lower its absorption. This could reduce antitumor efficacy.
What this interaction means in plain words
Calcium and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium belongs to Gastrointestinal Tract; Dabrafenib belongs to Oncology.
Why it happens
Elevated gastric pH reduces dissolution and bioavailability of dabrafenib.
What to do
Take dabrafenib on an empty stomach and separate it from antacids by at least 2 hours; monitor for loss of response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Dabrafenib
Frequently asked questions
Can I take Calcium with Dabrafenib?
MediHelp rates the interaction as moderate. Calcium and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib solubility is pH-dependent, so agents that raise gastric pH, including calcium carbonate antacids, may lower its absorption. This could reduce antitumor efficacy.
How serious is the interaction between Calcium and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take dabrafenib on an empty stomach and separate it from antacids by at least 2 hours; monitor for loss of response.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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