Drug interactions
Calcium + Dextroamphetamine
Severity: Minor
Calcium and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Agents that alkalinize urine reduce renal excretion of amphetamines, prolonging their effect. Calcium carbonate has only a mild alkalinizing effect, so the interaction is mostly relevant with large antacid doses.
What this interaction means in plain words
Calcium and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Urinary alkalinization increases the non-ionized fraction of amphetamine, enhancing tubular reabsorption.
What to do
Monitor for increased stimulant effects such as tachycardia or agitation when large antacid doses are used, and adjust the dextroamphetamine dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Calcium and Dextroamphetamine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Calcium with Dextroamphetamine?
MediHelp rates the interaction as minor. Calcium and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Agents that alkalinize urine reduce renal excretion of amphetamines, prolonging their effect. Calcium carbonate has only a mild alkalinizing effect, so the interaction is mostly relevant with large antacid doses.
How serious is the interaction between Calcium and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased stimulant effects such as tachycardia or agitation when large antacid doses are used, and adjust the dextroamphetamine dose.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
