Drug interactions
Calcium + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Moderate
Calcium and Elvitegravir / cobicistat / emtricitabine / tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Polyvalent cations such as calcium chelate elvitegravir in the gut, lowering its absorption and risking virologic failure and resistance. Labeling advises separation from antacids.
What this interaction means in plain words
Calcium and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of elvitegravir by calcium in the gastrointestinal tract.
What to do
Give the antacid at least 2 hours before or after the elvitegravir combination product; calcium supplements should also be spaced apart or taken together with food per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as moderate. Calcium and Elvitegravir / cobicistat / emtricitabine / tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Polyvalent cations such as calcium chelate elvitegravir in the gut, lowering its absorption and risking virologic failure and resistance. Labeling advises separation from antacids.
How serious is the interaction between Calcium and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the antacid at least 2 hours before or after the elvitegravir combination product; calcium supplements should also be spaced apart or taken together with food per labeling.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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