Drug interactions
Calcium + Estramustine
Severity: Moderate
Calcium and Estramustine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-containing products can bind estramustine in the gut and lower its absorption. Milk, dairy products and calcium supplements have been associated with reduced estramustine exposure, which could weaken its effect.
What this interaction means in plain words
Calcium and Estramustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Reduced oral absorption of estramustine through binding to calcium.
What to do
Take estramustine at least 1 hour before or 2 hours after meals, and avoid taking it with milk, dairy or calcium supplements and antacids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Estramustine?
MediHelp rates the interaction as moderate. Calcium and Estramustine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Calcium-containing products can bind estramustine in the gut and lower its absorption. Milk, dairy products and calcium supplements have been associated with reduced estramustine exposure, which could weaken its effect.
How serious is the interaction between Calcium and Estramustine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take estramustine at least 1 hour before or 2 hours after meals, and avoid taking it with milk, dairy or calcium supplements and antacids.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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