Drug interactions
Calcium + Fosamprenavir
Severity: Moderate
Calcium and Fosamprenavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids can reduce amprenavir exposure after fosamprenavir dosing, which may lessen antiviral effect. The reduction is thought to be modest.
What this interaction means in plain words
Calcium and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Altered gastric pH and binding in the gut reduce amprenavir absorption.
What to do
Separate fosamprenavir and antacid doses by at least 2 hours and monitor viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Fosamprenavir?
MediHelp rates the interaction as moderate. Calcium and Fosamprenavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antacids can reduce amprenavir exposure after fosamprenavir dosing, which may lessen antiviral effect. The reduction is thought to be modest.
How serious is the interaction between Calcium and Fosamprenavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate fosamprenavir and antacid doses by at least 2 hours and monitor viral load.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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