Drug interactions
Calcium + Gabapentin
Severity: Minor
Calcium and Gabapentin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Calcium-containing antacids can lower the amount of oral gabapentin absorbed, which may reduce seizure or pain control. The effect is modest and applies to oral products taken together.
What this interaction means in plain words
Calcium and Gabapentin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Calcium belongs to Gastrointestinal Tract; Gabapentin belongs to Central Nervous System.
Why it happens
Antacid cations reduce gastrointestinal absorption of gabapentin, probably through binding or reduced dissolution.
What to do
Give gabapentin at least 2 hours after calcium-containing antacids. Monitor seizure or pain control if timing cannot be separated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Other interactions of Gabapentin
Frequently asked questions
Can I take Calcium with Gabapentin?
MediHelp rates the interaction as minor. Calcium and Gabapentin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Calcium-containing antacids can lower the amount of oral gabapentin absorbed, which may reduce seizure or pain control. The effect is modest and applies to oral products taken together.
How serious is the interaction between Calcium and Gabapentin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give gabapentin at least 2 hours after calcium-containing antacids. Monitor seizure or pain control if timing cannot be separated.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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