Drug interactions
Calcium + Infigratinib
Severity: Moderate
Calcium and Infigratinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Infigratinib has pH-dependent solubility, and raising gastric pH can reduce its absorption. Lower exposure may reduce efficacy in cholangiocarcinoma treatment.
What this interaction means in plain words
Calcium and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antacid-induced rise in gastric pH decreases infigratinib solubility and absorption.
What to do
If an antacid cannot be avoided, take infigratinib 2 hours before or 2 hours after the locally acting antacid. Avoid proton pump inhibitors and H2 blockers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Calcium
- Calcium + Ceftriaxone Contraindicated
- Acalabrutinib + Calcium Moderate
- Alendronate + Calcium Moderate
- Atazanavir + Calcium Moderate
- Baloxavir marboxil + Calcium Moderate
- Bendroflumethiazide + Calcium Moderate
Frequently asked questions
Can I take Calcium with Infigratinib?
MediHelp rates the interaction as moderate. Calcium and Infigratinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Infigratinib has pH-dependent solubility, and raising gastric pH can reduce its absorption. Lower exposure may reduce efficacy in cholangiocarcinoma treatment.
How serious is the interaction between Calcium and Infigratinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If an antacid cannot be avoided, take infigratinib 2 hours before or 2 hours after the locally acting antacid. Avoid proton pump inhibitors and H2 blockers.
What other medicines interact with Calcium?
MediHelp also lists interactions of Calcium with, for example, Ceftriaxone, Acalabrutinib, Alendronate. The full list is on the Calcium page.
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